How the new era of psychedelic medicine is challenging the conventional model of depression — for the better.

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Psychedelics For Depression: How Does It Work?

Psychedelics themselves don’t cure depression. The real cure comes from the deep, personal insights gained during the experience. These insights change the way we think (unconsciously), which permeates into higher cognitive centers and alters our brain chemistry.

1. Psilocybin For Depression

There are numerous studies exploring the effects of psilocybin (the active ingredient in magic mushrooms) for mental health diseases — including depression.

Psilocybin acts as a serotonergic psychedelic — facilitating mystical and transformative experiences, enhancing suggestibility, and inducing neuroplasticity.

2. DMT & Ayahuasca For Depression

DMT (dimethyltryptamine) is one of the most powerful, yet short-lived psychedelics on Earth.

The power of DMT for healing depression lies in its reliability for inducing powerful mystical experiences.

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Its short duration (20–45 minutes) is advantageous over other psychedelics within the clinical setting too. It’s much easier for a therapist to administer a DMT session over the course of about an hour, rather than having to dedicate 6–10 hours for a single session with magic mushrooms or LSD .

This doesn’t apply to ayahuasca, a traditional plant medicine consisting of the ayahuasca vine (Banisteriopsis caapi) and a natural source of DMT (such as Mimosa pudica or Psychotria viridis). Ayahuasca ceremonies can last up to 12 hours and require the skill of a trained shaman.

3. Ketamine For Depression

Ketamine is unlike any antidepressant on the market today. It doesn’t target serotonin as SSRIs do, and it doesn’t induce mystical states like psilocybin, DMT, or LSD.

Psychedelic-Assisted Psychotherapy is Revolutionizing Healthcare

We’re on the brink of a revolution in the way we treat mental health as a society.

Evidence for the usefulness of psychedelics in mental health becomes stronger every day, and new bills are moving through the legal system that seeks to legalize psychedelic-assisted psychotherapy.

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