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> First things first: You may be asking yourself, "What is ketamine?" Well,
> it was once used mainly as an anesthetic on battlefields and in operating
> rooms. Now this medication is gaining ground as a promising treatment for
> cases of major depression, which is the leading cause of disability
> worldwide. In the US, recent estimates show 16 million adults had an
> episode of major depression in the course of a year. Suicide rates rose
> substantially between 1999 and 2016, increasing by more than 30% in 25
> states. Because of its rapid action, ketamine could have a role to play in
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> Why is ketamine exciting for treating depression?
>
> When an individual responds to ketamine, it can rapidly reduce suicidality
> (life-threatening thoughts and acts) and relieve other serious symptoms of
> depression. Ketamine also can be effective for treating depression combined
> with anxiety.
>
> What you know about ketamine
>
> A much lower dose of ketamine is given for depression compared with the
> dose necessary for anesthesia.Like opioids, ketamine has addictive
> properties. It’s important to understand this when weighing risks and
> benefits. If you have a history of substance abuse –– such as alcohol or
> drugs –– it’s especially important for you and your doctor to consider
> whether ketamine is a good option for you.
> When IV (racemic) ketamine works, people usually respond to it within one
> to three infusions. If a person has no response at all, further infusions
> are unlikely to help. Instead, it’s probably best to try other treatments
> for depression.
>
> People who experience some relief from depression within one to three
> ketamine treatments are probably likely to extend these positive effects if
> the treatment is repeated several more times. The subsequent sessions may
> help prolong the effects of ketamine, rather than achieving further
> dramatic relief of symptoms. There are no standard guidelines for this.
> Many studies offer eight treatments initially (acute phase). After this,
> patient and doctor decide whether to taper or stop ketamine treatments or
> continue treatments at longer intervals.
>
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