On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
>
> In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
>
> If anyone is personally familiar with this disorder, please inform.
> [ My email is daud....@gmail.com ]
>
> I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
>
> The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
>
> I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
>
> I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> ---
>
>
> The Conversation
>
> Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
>
> January 17, 2019 5.39am EST
> Janice Atkins, David Melzer, Luke Pilling, University of Exeter
>
> Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
>
> Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
>
> UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one.
>
> Severe consequences if not treated early
> Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
>
> The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
>
> Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
>
> Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
>
> If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
>
> The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies. People of southern European ancestry have about half that rate of the faulty genes.
>
> Treatment involves giving blood, which can then be reused.
>
> More screening is needed
> Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
>
> It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting..
>
> Feeling worn out? You could have iron overload
>
> Explainer: can the body have too much iron?
>
> Anaemia: why is it still affecting women?
>
> Should we edit out genetic disease?
> Sign in to comment2 Comments
>
> Lorraine Muller
> A very useful article. Thank you.
>
> 2 days ago
> Rolf Norolk
>
> Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
>
> http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
>
> Copyright © 2010–2019
> The Conversation US, Inc.
> -
> daud....@gmail.com
---
Update on personal journey

Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.

[Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]

I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.

The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.

Whole milk + natural meat -> high protein + high fat + low iron

Whole Milk
Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.

So 5 days meat and milk & low carb,
and 2 donor days low fat low carb high water high veg.

Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm., oats-whole grain-rice eve.
Progress.

On Thursday, November 10, 2022 at 8:24:47 AM UTC-5, Daud Deden wrote:
> On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> > Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
> >
> > In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
> >
> > If anyone is personally familiar with this disorder, please inform.
> > [ My email is daud....@gmail.com ]
> >
> > I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
> >
> > The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
> >
> > I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
> >
> > I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> > ---
> >
> >
> > The Conversation
> >
> > Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
> >
> > January 17, 2019 5.39am EST
> > Janice Atkins, David Melzer, Luke Pilling, University of Exeter
> >
> > Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
> >
> > Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
> >
> > UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one.
> >
> > Severe consequences if not treated early
> > Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
> >
> > The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
> >
> > Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
> >
> > Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
> >
> > If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
> >
> > The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies.. People of southern European ancestry have about half that rate of the faulty genes.
> >
> > Treatment involves giving blood, which can then be reused.
> >
> > More screening is needed
> > Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
> >
> > It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting.
> >
> > Feeling worn out? You could have iron overload
> >
> > Explainer: can the body have too much iron?
> >
> > Anaemia: why is it still affecting women?
> >
> > Should we edit out genetic disease?
> > Sign in to comment2 Comments
> >
> > Lorraine Muller
> > A very useful article. Thank you.
> >
> > 2 days ago
> > Rolf Norolk
> >
> > Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
> >
> > http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
> >
> > Copyright © 2010–2019
> > The Conversation US, Inc.
> > -
> > daud....@gmail.com
> ---
> Update on personal journey
>
> Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.
>
> [Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]
>
> I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.
>
> The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.
>
> Whole milk + natural meat -> high protein + high fat + low iron
>
> Whole Milk
> Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
> You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.
>
> So 5 days meat and milk & low carb,
> and 2 donor days low fat low carb high water high veg.
>
> Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm., oats-whole grain-rice eve.
> Progress.
-
Click here to read the complete article

On Thursday, November 10, 2022 at 8:37:31 AM UTC-5, Daud Deden wrote:
> On Thursday, November 10, 2022 at 8:24:47 AM UTC-5, Daud Deden wrote:
> > On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> > > Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
> > >
> > > In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
> > >
> > > If anyone is personally familiar with this disorder, please inform.
> > > [ My email is daud....@gmail.com ]
> > >
> > > I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
> > >
> > > The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
> > >
> > > I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
> > >
> > > I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> > > ---
> > >
> > >
> > > The Conversation
> > >
> > > Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
> > >
> > > January 17, 2019 5.39am EST
> > > Janice Atkins, David Melzer, Luke Pilling, University of Exeter
> > >
> > > Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
> > >
> > > Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
> > >
> > > UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one.
> > >
> > > Severe consequences if not treated early
> > > Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
> > >
> > > The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
> > >
> > > Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
> > >
> > > Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
> > >
> > > If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
> > >
> > > The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies. People of southern European ancestry have about half that rate of the faulty genes.
> > >
> > > Treatment involves giving blood, which can then be reused.
> > >
> > > More screening is needed
> > > Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
> > >
> > > It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting.
> > >
> > > Feeling worn out? You could have iron overload
> > >
> > > Explainer: can the body have too much iron?
> > >
> > > Anaemia: why is it still affecting women?
> > >
> > > Should we edit out genetic disease?
> > > Sign in to comment2 Comments
> > >
> > > Lorraine Muller
> > > A very useful article. Thank you.
> > >
> > > 2 days ago
> > > Rolf Norolk
> > >
> > > Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
> > >
> > > http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
> > >
> > > Copyright © 2010–2019
> > > The Conversation US, Inc.
> > > -
> > > daud....@gmail.com
> > ---
> > Update on personal journey
> >
> > Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.
> >
> > [Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]
> >
> > I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.
> >
> > The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.
> >
> > Whole milk + natural meat -> high protein + high fat + low iron
> >
> > Whole Milk
> > Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
> > You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.
> >
> > So 5 days meat and milk & low carb,
> > and 2 donor days low fat low carb high water high veg.
> >
> > Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm., oats-whole grain-rice eve.
> > Progress.
> -
> Regarding zinc, iron and nitrogen isotopes in neanderthal study (hyper carnivory, vegetarian, marine diet?) I see this article about zinc & iron absorption:
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722515/
---

On Thursday, November 10, 2022 at 2:15:20 PM UTC-5, Daud Deden wrote:
> On Thursday, November 10, 2022 at 8:37:31 AM UTC-5, Daud Deden wrote:
> > On Thursday, November 10, 2022 at 8:24:47 AM UTC-5, Daud Deden wrote:
> > > On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> > > > Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
> > > >
> > > > In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
> > > >
> > > > If anyone is personally familiar with this disorder, please inform.
> > > > [ My email is daud....@gmail.com ]
> > > >
> > > > I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
> > > >
> > > > The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
> > > >
> > > > I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
> > > >
> > > > I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> > > > ---
> > > >
> > > >
> > > > The Conversation
> > > >
> > > > Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
> > > >
> > > > January 17, 2019 5.39am EST
> > > > Janice Atkins, David Melzer, Luke Pilling, University of Exeter
> > > >
> > > > Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
> > > >
> > > > Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
> > > >
> > > > UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one.
> > > >
> > > > Severe consequences if not treated early
> > > > Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
> > > >
> > > > The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
> > > >
> > > > Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
> > > >
> > > > Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
> > > >
> > > > If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
> > > >
> > > > The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies. People of southern European ancestry have about half that rate of the faulty genes.
> > > >
> > > > Treatment involves giving blood, which can then be reused.
> > > >
> > > > More screening is needed
> > > > Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
> > > >
> > > > It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting.
> > > >
> > > > Feeling worn out? You could have iron overload
> > > >
> > > > Explainer: can the body have too much iron?
> > > >
> > > > Anaemia: why is it still affecting women?
> > > >
> > > > Should we edit out genetic disease?
> > > > Sign in to comment2 Comments
> > > >
> > > > Lorraine Muller
> > > > A very useful article. Thank you.
> > > >
> > > > 2 days ago
> > > > Rolf Norolk
> > > >
> > > > Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
> > > >
> > > > http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
> > > >
> > > > Copyright © 2010–2019
> > > > The Conversation US, Inc.
> > > > -
> > > > daud....@gmail.com
> > > ---
> > > Update on personal journey
> > >
> > > Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.
> > >
> > > [Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]
> > >
> > > I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.
> > >
> > > The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.
> > >
> > > Whole milk + natural meat -> high protein + high fat + low iron
> > >
> > > Whole Milk
> > > Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
> > > You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.
> > >
> > > So 5 days meat and milk & low carb,
> > > and 2 donor days low fat low carb high water high veg.
> > >
> > > Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm.., oats-whole grain-rice eve.
> > > Progress.
> > -
> > Regarding zinc, iron and nitrogen isotopes in neanderthal study (hyper carnivory, vegetarian, marine diet?) I see this article about zinc & iron absorption:
> > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722515/
> ---
>
> Dr. Sten Ekberg video about Low Carb, High Fat, Intermittent Fasting to control weight, the Keto diet. Primary: drop carbs to 5% to stop storing fat due to insulin response to consuming sugars and starches and excess protein (above 20%), leaving 75% fat consumption. Eating fat does not trigger insulin response yet gives energy, unlike other foods. Beef meat and fat, cheese, butter, milk are all good; ice cream is bad due to sugar. Fat satiates much better than sugar; MSG enhances flavor to taste buds inducing overeating of carbs. Good fats: (cold pressed) organic coconut oil, very fine olive oil, avocado,
> Being in ketosis (NOT ketoacidosis!) allows burning body fat for fuel without insulin causing storage hunger.
> Dr. Ekberg says that fat in blood, making it cloudy, is not bad for health, just bad for plasma machine filters.
> Some Plasma centers say avoid milk 24 hrs before donating, probably because of fat and because milk has casein, whey and calcium which block iron absorption.
>
> https://www.youtube.com/watch?v=RsLRUhC5Vn

On Thursday, November 10, 2022 at 11:57:14 PM UTC-5, Daud Deden wrote:
> On Thursday, November 10, 2022 at 2:15:20 PM UTC-5, Daud Deden wrote:
> > On Thursday, November 10, 2022 at 8:37:31 AM UTC-5, Daud Deden wrote:
> > > On Thursday, November 10, 2022 at 8:24:47 AM UTC-5, Daud Deden wrote:
> > > > On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> > > > > Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
> > > > >
> > > > > In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
> > > > >
> > > > > If anyone is personally familiar with this disorder, please inform.
> > > > > [ My email is daud....@gmail.com ]
> > > > >
> > > > > I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
> > > > >
> > > > > The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
> > > > >
> > > > > I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
> > > > >
> > > > > I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> > > > > ---
> > > > >
> > > > >
> > > > > The Conversation
> > > > >
> > > > > Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
> > > > >
> > > > > January 17, 2019 5.39am EST
> > > > > Janice Atkins, David Melzer, Luke Pilling, University of Exeter
> > > > >
> > > > > Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
> > > > >
> > > > > Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
> > > > >
> > > > > UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one..
> > > > >
> > > > > Severe consequences if not treated early
> > > > > Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
> > > > >
> > > > > The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
> > > > >
> > > > > Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
> > > > >
> > > > > Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
> > > > >
> > > > > If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
> > > > >
> > > > > The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies. People of southern European ancestry have about half that rate of the faulty genes.
> > > > >
> > > > > Treatment involves giving blood, which can then be reused.
> > > > >
> > > > > More screening is needed
> > > > > Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
> > > > >
> > > > > It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting.
> > > > >
> > > > > Feeling worn out? You could have iron overload
> > > > >
> > > > > Explainer: can the body have too much iron?
> > > > >
> > > > > Anaemia: why is it still affecting women?
> > > > >
> > > > > Should we edit out genetic disease?
> > > > > Sign in to comment2 Comments
> > > > >
> > > > > Lorraine Muller
> > > > > A very useful article. Thank you.
> > > > >
> > > > > 2 days ago
> > > > > Rolf Norolk
> > > > >
> > > > > Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
> > > > >
> > > > > http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
> > > > >
> > > > > Copyright © 2010–2019
> > > > > The Conversation US, Inc.
> > > > > -
> > > > > daud....@gmail.com
> > > > ---
> > > > Update on personal journey
> > > >
> > > > Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.
> > > >
> > > > [Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]
> > > >
> > > > I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.
> > > >
> > > > The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.
> > > >
> > > > Whole milk + natural meat -> high protein + high fat + low iron
> > > >
> > > > Whole Milk
> > > > Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
> > > > You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.
> > > >
> > > > So 5 days meat and milk & low carb,
> > > > and 2 donor days low fat low carb high water high veg.
> > > >
> > > > Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm., oats-whole grain-rice eve.
> > > > Progress.
> > > -
> > > Regarding zinc, iron and nitrogen isotopes in neanderthal study (hyper carnivory, vegetarian, marine diet?) I see this article about zinc & iron absorption:
> > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722515/
> > ---
> >
> > Dr. Sten Ekberg video about Low Carb, High Fat, Intermittent Fasting to control weight, the Keto diet. Primary: drop carbs to 5% to stop storing fat due to insulin response to consuming sugars and starches and excess protein (above 20%), leaving 75% fat consumption. Eating fat does not trigger insulin response yet gives energy, unlike other foods. Beef meat and fat, cheese, butter, milk are all good; ice cream is bad due to sugar. Fat satiates much better than sugar; MSG enhances flavor to taste buds inducing overeating of carbs. Good fats: (cold pressed) organic coconut oil, very fine olive oil, avocado,
> > Being in ketosis (NOT ketoacidosis!) allows burning body fat for fuel without insulin causing storage hunger.
> > Dr. Ekberg says that fat in blood, making it cloudy, is not bad for health, just bad for plasma machine filters.
> > Some Plasma centers say avoid milk 24 hrs before donating, probably because of fat and because milk has casein, whey and calcium which block iron absorption.
> >
> > https://www.youtube.com/watch?v=RsLRUhC5Vn
> Avoiding milk before donating is mainly for women with low iron, whereas most healthy men have higher iron, and men of NW Euro heritage have even higher iron storage.
>
> Dr. Ekberg has a video on exercise, run or walk: to burn fat, do low-stress fat-fueled aerobics daily and avoid high-stress glucose-fueled anaerobics, except in local muscles during moderate weight-lifting & calisthenics (muscles store some glucose/glycogen which can be burned without driving the liver's cortisol-> insulin response that stops fat burning.)
>
> So, best plan is: meat + milk + eggs + very low carbs + daily aerobics => fat burning + protein building muscle w/o iron overload or type 2 diabetes, preferably bare feet fitness with little sweat and well hydrated. DD

On Friday, November 11, 2022 at 9:03:27 PM UTC-5, Daud Deden wrote:
> On Thursday, November 10, 2022 at 11:57:14 PM UTC-5, Daud Deden wrote:
> > On Thursday, November 10, 2022 at 2:15:20 PM UTC-5, Daud Deden wrote:
> > > On Thursday, November 10, 2022 at 8:37:31 AM UTC-5, Daud Deden wrote:
> > > > On Thursday, November 10, 2022 at 8:24:47 AM UTC-5, Daud Deden wrote:
> > > > > On Saturday, January 19, 2019 at 10:33:58 PM UTC-5, Daud Deden wrote:
> > > > > > Article from Conversation.com about H(a)emochromatosis genetic disorder where blood & organs accumulate too much iron, due to c282y Gene mutation (one or 2 gene copies). I strongly suspect I have this, probably the single copy type, and will try to get tested. It is most common in northwestern Europe, especially Scotland, Ireland, Norway.
> > > > > >
> > > > > > In a loose sense, it is like the spectral 'opposite' of sickle cell, thallasemia or other types of anemia.
> > > > > >
> > > > > > If anyone is personally familiar with this disorder, please inform.
> > > > > > [ My email is daud....@gmail.com ]
> > > > > >
> > > > > > I know there was a study of Norwegian blood plasma donors who were former blood donors that gradually developed higher than expected blood iron. I have exactly the same situation, despite limiting my dietary iron. I suspect some of my earlier kin had this condition and never knew, and had resulting health problems. I have incipient hip arthritis which I had thought due to motorcycle accident, Lyme disease and/or genes, but this disorder seems more likely, I have Scottish, Irish, Danish, French & German ancestry (and other).
> > > > > >
> > > > > > The article goes into how Hunting-fishing-gathering people in North Europe switched to agriculture and that was related to this. I'm interested in that as well, the ecological & cultural aspects.
> > > > > >
> > > > > > I didn't know that Ernest Hemingway had this "Celtic Curse" and suffered from it.
> > > > > >
> > > > > > I became aware of it by a dietician (at AAT) saying that artherisclerosis(spell) is when the body coats arteries with waxy layer to reduce contact with too-high-iron blood, and that blockage results due to a diet of both high-iron and high-fat food eg. fatty beef.
> > > > > > ---
> > > > > >
> > > > > >
> > > > > > The Conversation
> > > > > >
> > > > > > Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
> > > > > >
> > > > > > January 17, 2019 5.39am EST
> > > > > > Janice Atkins, David Melzer, Luke Pilling, University of Exeter
> > > > > >
> > > > > > Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple. It involves donating blood to bring iron levels down.
> > > > > >
> > > > > > Over the last 15 years, our research group at the University of Exeter has focused on the question: why are some older people ill and frail in their sixties while others remain active and disease free into their nineties and beyond. In our most recent study, we used data from the UK Biobank, which contains genetic and medical data from half a million people, to find genes associated with muscle ageing, searching across people’s DNA. To our surprise, we found a link between the haemochromatosis gene and muscle weakness, chronic pain and frailty in the older people in the study who weren’t diagnosed with haemochromatosis.
> > > > > >
> > > > > > UK Biobank studied 500,000 volunteers who were interviewed when they were 40 to 70 years old, and we have data from their hospital records for an average of seven years after the interview. We were able to study 2,890 people with both faulty haemochromatosis genes (called HFE C282Y mutations), making the study nearly ten times larger than any previous similar one.
> > > > > >
> > > > > > Severe consequences if not treated early
> > > > > > Our papers, in the BMJ and the Journal of Gerontology: Medical Sciences, report that those with the two faulty genes have quadruple the rates of liver disease and double the rates of arthritis and frailty compared with the general population. They also have higher rates of liver cancer, diabetes (both type 1 and type 2), chronic pain and tiredness. Both the younger (40- to 59-year-olds) and the older group (60 to 70) were affected.
> > > > > >
> > > > > > The more severe effects of the faulty genes are fairly frequently seen in healthcare. Of all the hip replacements in men in the UK Biobank study, 1.6% were in men with the two faulty genes. Nearly 6% of all the liver cancers in the study were also in people with the faulty genes.
> > > > > >
> > > > > > Women tend to be diagnosed with haemochromatosis at older ages than men, as they have partial protection from losing iron through menstruation and having children, although some younger women do develop the disease.
> > > > > >
> > > > > > Most of the excess liver disease, arthritis, diabetes, tiredness, pain and muscle weakness could be prevented if treatment is started before damage from excess iron sets in. To maintain low iron levels, people with the two faulty genes need to give blood three or four times a year. The blood can even be used by others for transfusion – a rare win-win.
> > > > > >
> > > > > > If the disease is left untreated, very high iron levels can build up causing permanent damage, and blood might have to be taken once every two weeks for a year and destroyed. Economic models show that routine screening of people of European ancestry for haemochromatosis would more than pay for itself.
> > > > > >
> > > > > > The iron absorption mutation may have become common when hunter-gatherers switched to agriculture in low iron areas, over 10,000 years ago.. Between 10 and 15% of people with northern European ancestry carry one copy of the C282Y mutation, with about one in 150 inheriting the high-risk two copies. People of southern European ancestry have about half that rate of the faulty genes.
> > > > > >
> > > > > > Treatment involves giving blood, which can then be reused.
> > > > > >
> > > > > > More screening is needed
> > > > > > Symptoms of haemochromatosis are not easy to diagnose without specific blood or genetic testing. The joint pains and arthritis in haemochromatosis develop in a similar way to osteoarthritis, with the differences between the two being difficult to spot. Of course, doctors see many patients with tiredness, most of whom don’t have haemochromatosis. The joint pains and tiredness are sometimes mistaken as “normal” signs of ageing by both patients and doctors. It is only when the more severe damage is done to the liver that the disease becomes easier to recognise.
> > > > > >
> > > > > > It is clear that routine testing is needed if patients are to be identified early enough, and it is exciting to think that such a large amount of disease could be avoided by such a simple treatment. The prospect of halving frailty rates in older people with these faulty genes is also very exciting.
> > > > > >
> > > > > > Feeling worn out? You could have iron overload
> > > > > >
> > > > > > Explainer: can the body have too much iron?
> > > > > >
> > > > > > Anaemia: why is it still affecting women?
> > > > > >
> > > > > > Should we edit out genetic disease?
> > > > > > Sign in to comment2 Comments
> > > > > >
> > > > > > Lorraine Muller
> > > > > > A very useful article. Thank you.
> > > > > >
> > > > > > 2 days ago
> > > > > > Rolf Norolk
> > > > > >
> > > > > > Ernest Hemingway a notable sufferer (please also note the site below is devoted to the disease):
> > > > > >
> > > > > > http://celticcurse.org/hemingways-death-and-hemochromatosis-awareness/
> > > > > >
> > > > > > Copyright © 2010–2019
> > > > > > The Conversation US, Inc.
> > > > > > -
> > > > > > daud....@gmail.com
> > > > > ---
> > > > > Update on personal journey
> > > > >
> > > > > Ok, to review, I tend to hoard iron, I donate blood plasma 2x a week (my hematocrit is always higher and protein lower than optimal, fat w/in 12 hrs of donating causes cloudy blood which slows donation), bicycle 5mi 5x a week, lift weights & stretch & light calisthenics 3x a week, had medium carb low fat diet, now switching to paleo-keto diet of higher fat higher meat low sugar low starch in order to maintain health and reduce some visceral and subcutaneous fat.
> > > > >
> > > > > [Working out for 6 mo. at PF, still can't see my 6pack abs, but muscles & fat are much better. Doing barefoot pushups, situps, lunges, 20 min. fast walks w/ 10lb dumbells, no pullups/chinups due to shoulder injury. Got crowned, oralB & waterpik yesterday, dental health much better in last 6 mo, will improve, still $30k work to do.]
> > > > >
> > > > > I find that whole milk inhibits iron absorption via whey, casein and calcium. So 12 hours before donation, no milk, not fatty meat, yes whey, yes much freshwater & a protein drink of low fat low iron low Vit C, light exercise aerobics 2hrs before, no lifting after, no caffeine or alcohol before or until after 2hrs of post-donation hydration.
> > > > >
> > > > > The paleo-keto diet can work with plasma donation and weight lifting, with a few caveats.
> > > > >
> > > > > Whole milk + natural meat -> high protein + high fat + low iron
> > > > >
> > > > > Whole Milk
> > > > > Whole milk (containing 3.25 percent fat) has about 150 calories, 8 grams of protein and 8 grams of fat per cup.
> > > > > You might feel fuller from a higher fat intake — aka drinking whole milk — which can reduce overall calorie intake throughout the day. People who consumed full-fat dairy gained less weight than those who stuck to low-fat dairy products, according to April 2016 research published in the ​American Journal of Clinical Nutrition​.
> > > > >
> > > > > So 5 days meat and milk & low carb,
> > > > > and 2 donor days low fat low carb high water high veg.
> > > > >
> > > > > Daily: Avocado & 3 raw egg & whey+stevia decaf in am., milk & meat pm., oats-whole grain-rice eve.
> > > > > Progress.
> > > > -
> > > > Regarding zinc, iron and nitrogen isotopes in neanderthal study (hyper carnivory, vegetarian, marine diet?) I see this article about zinc & iron absorption:
> > > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722515/
> > > ---
> > >
> > > Dr. Sten Ekberg video about Low Carb, High Fat, Intermittent Fasting to control weight, the Keto diet. Primary: drop carbs to 5% to stop storing fat due to insulin response to consuming sugars and starches and excess protein (above 20%), leaving 75% fat consumption. Eating fat does not trigger insulin response yet gives energy, unlike other foods. Beef meat and fat, cheese, butter, milk are all good; ice cream is bad due to sugar. Fat satiates much better than sugar; MSG enhances flavor to taste buds inducing overeating of carbs. Good fats: (cold pressed) organic coconut oil, very fine olive oil, avocado,
> > > Being in ketosis (NOT ketoacidosis!) allows burning body fat for fuel without insulin causing storage hunger.
> > > Dr. Ekberg says that fat in blood, making it cloudy, is not bad for health, just bad for plasma machine filters.
> > > Some Plasma centers say avoid milk 24 hrs before donating, probably because of fat and because milk has casein, whey and calcium which block iron absorption.
> > >
> > > https://www.youtube.com/watch?v=RsLRUhC5Vn
> > Avoiding milk before donating is mainly for women with low iron, whereas most healthy men have higher iron, and men of NW Euro heritage have even higher iron storage.
> >
> > Dr. Ekberg has a video on exercise, run or walk: to burn fat, do low-stress fat-fueled aerobics daily and avoid high-stress glucose-fueled anaerobics, except in local muscles during moderate weight-lifting & calisthenics (muscles store some glucose/glycogen which can be burned without driving the liver's cortisol-> insulin response that stops fat burning.)
> >
> > So, best plan is: meat + milk + eggs + very low carbs + daily aerobics => fat burning + protein building muscle w/o iron overload or type 2 diabetes, preferably bare feet fitness with little sweat and well hydrated. DD
> Shellfish and crustaceans have meat. Unfortunately, oysters and some clams (farmed?) have very high heme iron content (much higher than beef), so I must avoid eating them before donating blood plasma. *Afterwards*, I usually get a tin of delicious smoked oysters and some shrimp or a steak for the grill, and some cold beer.
>
> My speculation is that NW European males (UK, Scandinavia: cloudy chilly climate) developed genetic propensity for iron overload (hemochromatosis) due to a heavy reliance on domestic dairy products which blocked iron absorption. I don't know if the ancient H&G people of that region also had iron overload, or if it was common only among dairy-dependent farmers that arrived later.